Protein Variants | Comment | Organism |
---|---|---|
IF-KH I331F/K359H | the mutant is competent for copy-choice recombination | Enterovirus C |
IF-PS-KH I331F/P356S/K359H | the triple mutant replicates even faster but still exhibits a significant reduction in the rate of replication relative to wild-type enzyme. The virus is impaired substantially for recombination in cells | Enterovirus C |
K359H | the mutant enzyme catalyzes nucleotidyl transfer at a rate 10fold lower than wild-type. K359H poliovirus is genetically unstable and acquires mutations encoding two second-site amino acid substitutions after a few passages in cell cultures | Enterovirus C |
K359R | the mutant enzyme catalyzes nucleotidyl transfer at a rate 10fold lower than wild-type | Enterovirus C |
PS-KH P356S/K359H | the mutant is competent for forced-copy-choice recombination | Enterovirus C |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | Enterovirus C | - |
diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterovirus C | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | - |
Enterovirus C | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RDRP | - |
Enterovirus C |
RNA-dependent RNA polymerase | - |
Enterovirus C |